Efficacy and Duration of Benazepril Plus Amlodipine or Hydrochlorthiazide on 24-Hour Ambulatory Systolic Blood Pressure Control

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  • Kenneth A. Jamerson
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Richard Devereux
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • George L. Bakris
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Björn Dahlöf
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Bertram Pitt
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Eric J. Velazquez
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Matthew Weir
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Roxzana Y. Kelly
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Tsushung A. Hua
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Allen Hester
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...
  • Michael A. Weber
    From the University of Michigan Health System (K.A.J., B.P.), Ann Arbor, MI; The New York Hospital, Cornell Medical Center (R.D.), New York, NY; University of Chicago Pritzker School of Medicine (G.L.B.), Chicago, IL; Sahlgrenska University Hospital (B.D.), Gothenburg, Sweden; Duke University School of Medicine (E.J.V.), Durham, NC; University of Maryland School of Medicine (M.W.), Baltimore, MD; Novartis Pharmaceuticals (R.Y.K., T.A.H., A.H.), East Hanover, NJ; and State University of New York...

Description

<jats:p> The combination of benazepril plus amlodipine was shown to be more effective than benazepril plus hydrochlorothiazide in reducing cardiovascular events in the Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial. There was a small difference in clinic systolic blood pressure between the treatment arms favoring benazepril plus amlodipine. Ambulatory blood pressure monitoring provides a more rigorous estimate of blood pressure effects. A subset of 573 subjects underwent ambulatory blood pressure monitoring during year 2. Readings were obtained every 20 minutes during a 24-hour period. Between-treatment differences (benazepril plus amlodipine versus benazepril plus hydrochlorothiazide) in mean values were analyzed using ANOVA. Treatment comparisons with respect to categorical variables were made using Pearson's χ <jats:sup>2</jats:sup> . At year 2, the treatment groups did not differ significantly in 24-hour mean daytime or nighttime blood pressures (values of 123.9, 125.9, and 118.1 mm Hg for benazepril plus amlodipine group versus 122.3, 124.1, and 116.9 for the benazepril plus hydrochlorothiazide group), with mean between-group differences of 1.6, 1.8, and 1.2 mm Hg, respectively. Blood pressure control rates (24-hour mean systolic blood pressure <130 mm Hg on ambulatory blood pressure monitoring) were greater than 80% in both groups. Nighttime systolic blood pressure provided additional risk prediction after adjusting for the effects of drugs. The 24-hour blood pressure control was similar in both treatment arms, supporting the interpretation that the difference in cardiovascular outcomes favoring a renin angiotensin system blocker combined with amlodipine rather than hydrochlorothiazide shown in the ACCOMPLISH trial was not caused by differences in blood pressure, but instead intrinsic properties (metabolic or hemodynamic) of the combination therapies. </jats:p>

Journal

  • Hypertension

    Hypertension 57 (2), 174-179, 2011-02

    Ovid Technologies (Wolters Kluwer Health)

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