Repulsive Guidance Molecule Plays Multiple Roles in Neuronal Differentiation and Axon Guidance
書誌事項
- 公開日
- 2006-05-31
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by-nc-sa/4.0/
- DOI
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- 10.1523/jneurosci.4556-05.2006
- 公開者
- Society for Neuroscience
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説明
<jats:p>Repulsive guidance molecule (RGM) is a membrane-bound protein originally isolated as a guidance molecule for retinal axons. Three RGM isoforms (RGMa–RGMc) exist in vertebrates. We showed previously that RGMa is a cell-survival factor in the neuroepithelium of chick embryos that suppresses the proapoptotic activity of its receptor neogenin. In the present study, we performed gain- and loss-of-function analysis of RGMa in chick embryos to further investigate RGMa function. We found that RGMa overexpression promotes neuronal differentiation, whereas<jats:italic>RGMa</jats:italic>small interference RNA represses it. Similar experiments conducted at later developmental stages using retroviral vectors reveal that perturbation of<jats:italic>RGMa</jats:italic>expression disturbs the retinotectal projection. Our work provides the first evidence for a role for RGMs in axon guidance<jats:italic>in vivo</jats:italic>. In addition, these results suggest that RGMa exerts multiple functions during neural development.</jats:p>
収録刊行物
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- The Journal of Neuroscience
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The Journal of Neuroscience 26 (22), 6082-6088, 2006-05-31
Society for Neuroscience
