Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-γ) Promoter and Subsequent Downregulation of IFN-γ Production

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  • Judy A. Mikovits
    1Intramural Research Support Program, SAIC Frederick
  • Howard A. Young
    2Laboratory of Experimental Immunology
  • Paula Vertino
    3Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231
  • Jean-Pierre J. Issa
    3Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231
  • Paula M. Pitha
    3Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231
  • Susan Turcoski-Corrales
    4CBER, Rockville, Maryland 20892
  • Dennis D. Taub
    5Laboratory of Immunology, National Institute of Aging, Baltimore, Maryland 21224
  • Cari L. Petrow
    1Intramural Research Support Program, SAIC Frederick
  • Stephen B. Baylin
    3Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231
  • Francis W. Ruscetti
    6Laboratory of Leukocyte Biology,Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick Maryland 21702-1201

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