Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri
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- T L Talarico
- Department of Microbiology, North Carolina State University, Raleigh 27695.
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- I A Casas
- Department of Microbiology, North Carolina State University, Raleigh 27695.
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- T C Chung
- Department of Microbiology, North Carolina State University, Raleigh 27695.
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- W J Dobrogosz
- Department of Microbiology, North Carolina State University, Raleigh 27695.
書誌事項
- 公開日
- 1988-12
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/aac.32.12.1854
- 公開者
- American Society for Microbiology
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説明
<jats:p>Lactobacillus reuteri is a prominent member of the Lactobacillus population in the gastrointestinal ecosystem of humans, poultry, swine, and other animals. Reuterin is a newly discovered, broad-spectrum antimicrobial substance produced by this species during fermentation of glycerol. In this report, we describe procedures for (i) producing reuterin in sufficient amounts to isolate from a fermentation mixture and (ii) isolating this substance by high-performance liquid chromatography. By using uniformly labeled [14C]glycerol, reuterin was identified as a product of glycerol fermentation associated with the production of beta-hydroxypropionic acid and trimethylene glycol.</jats:p>
収録刊行物
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 32 (12), 1854-1858, 1988-12
American Society for Microbiology