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- Hiroshi Nikaido
- Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202;
書誌事項
- 公開日
- 2009-06-01
- DOI
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- 10.1146/annurev.biochem.78.082907.145923
- 公開者
- Annual Reviews
この論文をさがす
説明
<jats:p> Large amounts of antibiotics used for human therapy, as well as for farm animals and even for fish in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. Multidrug resistance in bacteria may be generated by one of two mechanisms. First, these bacteria may accumulate multiple genes, each coding for resistance to a single drug, within a single cell. This accumulation occurs typically on resistance (R) plasmids. Second, multidrug resistance may also occur by the increased expression of genes that code for multidrug efflux pumps, extruding a wide range of drugs. This review discusses our current knowledge on the molecular mechanisms involved in both types of resistance. </jats:p>
収録刊行物
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- Annual Review of Biochemistry
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Annual Review of Biochemistry 78 (1), 119-146, 2009-06-01
Annual Reviews
