Analysis of heart injury laboratory parameters in 273 COVID‐19 patients in one hospital in Wuhan, China

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  • Huan Han
    Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan Hubei China
  • Linlin Xie
    Department of Medical Microbiology, State Key Laboratory of Virology School of Basic Medical Sciences Wuhan Hubei China
  • Rui Liu
    Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan Hubei China
  • Jie Yang
    Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan Hubei China
  • Fang Liu
    Department of Virology, State Key Laboratory of Virology College of Life Sciences Wuhan Hubei China
  • Kailang Wu
    Department of Virology, State Key Laboratory of Virology College of Life Sciences Wuhan Hubei China
  • Lang Chen
    Department of Medical Microbiology, State Key Laboratory of Virology School of Basic Medical Sciences Wuhan Hubei China
  • Wei Hou
    Department of Medical Microbiology, State Key Laboratory of Virology School of Basic Medical Sciences Wuhan Hubei China
  • Yong Feng
    Department of Medical Microbiology, State Key Laboratory of Virology School of Basic Medical Sciences Wuhan Hubei China
  • Chengliang Zhu
    Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan Hubei China

書誌事項

公開日
2020-04-15
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/jmv.25809
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>An outbreak of severe acute respiratory syndrome novel coronavirus (SARS‐CoV‐2) epidemic spreads rapidly worldwide. SARS‐CoV‐2 infection caused mildly to seriously and fatally respiratory, enteric, cardiovascular, and neurological diseases. In this study, we detected and analyzed the main laboratory indicators related to heart injury, creatine kinase isoenzyme‐MB (CK‐MB), myohemoglobin (MYO), cardiac troponin I (ultra‐TnI), and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), in 273 patients with COVID‐19 and investigated the correlation between heart injury and severity of the disease. It was found that higher concentration in venous blood of CK‐MB, MYO, ultra‐TnI, and NT<jats:bold>‐</jats:bold>proBNP were associated with the severity and case fatality rate of COVID‐19. Careful monitoring of the myocardiac enzyme profiles is of great importance in reducing the complications and mortality in patients with COVID‐19.</jats:p>

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