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- Christopher J. Ackerson
- Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305
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- Michael T. Sykes
- Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305
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- Roger D. Kornberg
- Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305
説明
<jats:p>Glutathione monolayer-protected gold clusters were reacted by place exchange with 19- or 20-residue thiolated oligonucleotides. The resulting DNA/nanoparticle conjugates could be separated on the basis of the number of bound oligonucleotides by gel electrophoresis and assembled with one another by DNA-DNA hybridization. This approach overcomes previous limitations of DNA/nanoparticle synthesis and yields conjugates that are precisely defined with respect to both gold and nucleic acid content.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 102 (38), 13383-13385, 2005-09-09
Proceedings of the National Academy of Sciences