The TRIM5α Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge
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- Matthew R. Reynolds
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
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- Jonah B. Sacha
- Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 NW 185th Ave., Beaverton, Oregon 97006
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- Andrea M. Weiler
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
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- Gretta J. Borchardt
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
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- Chrystal E. Glidden
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
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- Neil C. Sheppard
- Vaccine Research, Worldwide Research and Development, Pfizer Inc., 10777 Science Center Drive, San Diego, California 92121
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- Francesca A. Norante
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
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- Philip A. Castrovinci
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
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- Jacqueline J. Harris
- Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294
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- Henry T. Robertson
- Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294
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- Thomas C. Friedrich
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
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- Adrian B. McDermott
- International AIDS Vaccine Initiative, New York, New York 10038
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- Nancy A. Wilson
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
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- David B. Allison
- Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294
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- Wayne C. Koff
- International AIDS Vaccine Initiative, New York, New York 10038
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- Welkin E. Johnson
- New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts
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- David I. Watkins
- AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
抄録
<jats:title>ABSTRACT</jats:title> <jats:p> It has recently been shown that polymorphism at the rhesus macaque <jats:italic>TRIM5</jats:italic> locus can affect simian immunodeficiency virus (SIV) replication. Here we show that <jats:italic>TRIM5</jats:italic> alleles can also affect acquisition of SIVsmE660. Animals coexpressing the <jats:italic>TRIM5</jats:italic> <jats:sup> <jats:italic>TFP</jats:italic> </jats:sup> and <jats:italic>TRIM5</jats:italic> <jats:sup> <jats:italic>CypA</jats:italic> </jats:sup> alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing other <jats:italic>TRIM5</jats:italic> allele combinations. Our results indicate that the <jats:italic>TRIM5</jats:italic> alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses. </jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 85 (18), 9637-9640, 2011-09-15
American Society for Microbiology