Quantitative Determination of Principal Aporphine and Benzylisoquinoline Alkaloids Due to Blooming State in Lotus Flower (Flower Buds of <i>Nelumbo nucifera</i>) and Their Hyaluronidase Inhibitory Activity
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- Toshio Morikawa
- Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Japan
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- Shuhei Okugawa
- Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Japan
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- Yoshiaki Manse
- Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Japan
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- Osamu Muraoka
- Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Japan
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- Masayuki Yoshikawa
- Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Japan
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- Kiyofumi Ninomiya
- Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Japan
抄録
<jats:p> Using a recently developed analytical protocol, distributions of 5 aporphine alkaloids, nuciferine (1), nornuciferine (2), N-methylasimilobine (3), asimilobine (4), and pronuciferine (5), and 5 benzylisoquinoline alkaloids, armepavine (6), norarmepavine (7), N-methylcoclaurine (8), coclaurine (9), and norjuziphine (10), in lotus flowers (the flower buds of Nelumbo nucifera) were analyzed. The flowers were collected at different blooming states (beginning of blooming, one-third in bloom, half in bloom, three-quarters in bloom, and in full bloom) from Saga prefecture, Japan (NN-S1–5). The samples from the beginning of blooming state (NN-S1, 16.35 mg/g in dried material) were found to possess the richest total alkaloid content (1-10). The samples of half in bloom (NN-S3, 52.69 mg per flower of dried material) had the highest total alkaloid content per flower. Among the alkaloid constituents, nornuciferine (2, IC<jats:sub>50</jats:sub> = 22.5 µM), asimilobine (4, 11.7 μM), norarmepavine (7, 26.4 μM), coclaurine (9, 11.4 μM), and norjuziphine (10, 24.3 μM) exhibited hyaluronidase inhibitory activity, which was more potent than that of the antiallergic medicine disodium cromoglycate (DSCG, 64.8 μM). </jats:p>
収録刊行物
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- Natural Product Communications
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Natural Product Communications 14 (6), 1934578X1985783-, 2019-06
SAGE Publications
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詳細情報 詳細情報について
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- CRID
- 1361412896669214848
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- ISSN
- 15559475
- 1934578X
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- データソース種別
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- Crossref
- KAKEN