Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
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- Brian J. DeBosch
- Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Monique R. Heitmeier
- Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Allyson L. Mayer
- Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Cassandra B. Higgins
- Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Jan R. Crowley
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Thomas E. Kraft
- Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Maggie Chi
- Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Elizabeth P. Newberry
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Zhouji Chen
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Brian N. Finck
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Nicholas O. Davidson
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Kevin E. Yarasheski
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Paul W. Hruz
- Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Kelle H. Moley
- Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.
説明
<jats:p>The disaccharide trehalose blocks glucose uptake in hepatocytes and induces autophagy that prevents fatty liver disease.</jats:p>
収録刊行物
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- Science Signaling
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Science Signaling 9 (416), ra21-, 2016-02-23
American Association for the Advancement of Science (AAAS)
