Early-life stress has persistent effects on amygdala function and development in mice and humans

DOI Web Site 4 Citations
  • Matthew Malter Cohen
    Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065;
  • Deqiang Jing
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065; and
  • Rui R. Yang
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065; and
  • Nim Tottenham
    Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065;
  • Francis S. Lee
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065; and
  • B. J. Casey
    Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065;

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<jats:title>Significance</jats:title> <jats:p>The current study provides evidence of early and persistent alterations in anxious behavior and amygdala function following the early-life stress of disorganized parental care. These changes in both brain and behavior are not diminished when the stressor is removed nor diminished with the development of prefrontal regulatory regions. The findings underscore the importance of early-life experiences on later development and highlight the need for early intervention for populations at-risk following early-life stressors.</jats:p>

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