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Rapid and highly sensitive high-performance liquid chromatographic method for the determination of histamine and 3-methylhistamine in biological samples using fluorescamine as the derivatizing agent
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Description
A highly sensitive and rapid high-performance liquid chromatographic assay for the determination of histamine and 3-methylhistamine in biological samples using 1-methylhistamine as the internal standard is described. Samples were purified and concentrated on cation-exchange columns and derivatized with fluorescamine. The lower detection limit was 20 pg on-column. Linearity was demonstrated up to 20 ng on-column. The samples could be derivatized simultaneously before injection and were stable for 7 days. The method was used for the determination of histamine and related compounds in coronary perfusates, extracts of homogenized rat hearts, and supernatants of stimulated peritoneal mast cells.
Journal
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- Journal of Chromatography B: Biomedical Sciences and Applications
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Journal of Chromatography B: Biomedical Sciences and Applications 657 (1), 261-, 1994-07
Elsevier BV
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Details 詳細情報について
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- CRID
- 1361418518482992768
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- ISSN
- 03784347
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- Web Site
- https://api.elsevier.com/content/article/PII:0378434794800987?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:0378434794800987?httpAccept=text/plain
- https://api.elsevier.com/content/article/PII:037843479380493N?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:037843479380493N?httpAccept=text/plain
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- Data Source
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- Crossref
- OpenAIRE