Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis
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- Michael S. Pepper
- From the Department of Morphology, University Medical Center, Geneva, Switzerland.
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Abstract
<jats:p> <jats:italic>Abstract</jats:italic> —Extracellular proteolysis is an absolute requirement for new blood vessel formation (angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and plasminogen activator (PA)–plasmin systems during angiogenesis. Specifically, a role for gelatinases (MMP-2, MMP-9), membrane-type 1 MMP (MMP-14), the urokinase-type PA receptor, and PA inhibitor 1 has been clearly defined in a number of model systems. The MMP and PA-plasmin systems have also been implicated in experimental vascular tumor formation, and their role during this process will be examined. Antiproteolysis, particularly in the context of angiogenesis, has become a key target in therapeutic strategies aimed at inhibiting tumor growth and other diseases associated with neovascularization. </jats:p>
Journal
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- Arteriosclerosis, Thrombosis, and Vascular Biology
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Arteriosclerosis, Thrombosis, and Vascular Biology 21 (7), 1104-1117, 2001-07
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1361418518483910272
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- NII Article ID
- 30029758989
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- NII Book ID
- AA11029972
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- ISSN
- 15244636
- 10795642
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- Data Source
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- Crossref
- CiNii Articles