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- Melina Paula Bordone
- Facultad de Farmacia y Bioquímica Instituto de Investigaciones Farmacológicas (ININFA) Universidad de Buenos Aires Buenos Aires Argentina
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- Mootaz M. Salman
- Department of Cell Biology Harvard Medical School, and Program in Cellular and Molecular Medicine Boston Children's Hospital Boston Massachusetts USA
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- Haley E. Titus
- Feinberg School of Medicine Northwestern University Chicago Illinois USA
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- Elham Amini
- Department of Medicine University Kebangsaan Malaysia Medical Centre (HUKM) Cheras, Kuala Lumpur Malaysia
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- Jens V. Andersen
- Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark
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- Barnali Chakraborti
- Manovikas Kendra Kolkata India
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- Artem V. Diuba
- Belozersky Institute of Physico‐Chemical Biology Lomonosov Moscow State University Moscow Russia
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- Tatsiana G. Dubouskaya
- Institute of Biophysics and Cell Engineering National Academy of Sciences of Belarus Minsk Belarus
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- Eric Ehrke
- Centre for Biomolecular Interactions University of Bremen Bremen Germany
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- Andiara Espindola de Freitas
- Neurobiology Section Biological Sciences Division University of California San Diego, La Jolla California USA
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- Guilherme Braga de Freitas
- Institute of Medical Biochemistry Federal University of Rio de Janeiro Rio de Janeiro Brazil
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- Rafaella A. Gonçalves
- Centre for Neuroscience Studies Queen's University Kingston Ontario Canada
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- Deepali Gupta
- BITS Pilani Pilani India
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- Richa Gupta
- CSIR‐Indian Institute of Toxicology Research Lucknow India
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- Sharon R. Ha
- Baylor College of Medicine Houston Texas USA
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- Isabel A. Hemming
- Brain Growth and Disease Laboratory The Harry Perkins Institute of Medical Research Nedlands Western Australia Australia
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- Minal Jaggar
- Department of Biological Sciences Tata Institute of Fundamental Research Mumbai India
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- Emil Jakobsen
- Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark
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- Punita Kumari
- Defense Institute of Physiology and allied sciences Defense Research and Development Organization Timarpur, Delhi India
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- Navya Lakkappa
- Department of Pharmacology JSS college of Pharmacy Ooty India
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- Ashley P. L. Marsh
- Bruce Lefroy Centre for Genetic Health Research Murdoch Children's Research Institute Royal Children's Hospital Parkville Victoria Australia
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- Jessica Mitlöhner
- Department of Neurochemistry and Molecular Biology Leibniz Institute for Neurobiology Magdeburg Magdeburg Germany
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- Yuki Ogawa
- The Jikei University School of Medicine Minato‐ku Tokyo Japan
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- Ramesh Kumar Paidi
- CSIR‐Indian Institute of Chemical Biology Kolkata India
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- Felipe C. Ribeiro
- Federal University of Rio de Janeiro Rio de Janeiro Brazil
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- Ahmad Salamian
- Department of Molecular and Cellular Neurobiology Nencki Institute of Experimental Biology Polish Academy of Sciences Warsaw Poland
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- Suraiya Saleem
- CSIR‐Indian Institute of Chemical Biology Kolkata India
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- Sorabh Sharma
- Department of Pharmacy Birla Institute of Technology and Science Pilani Rajasthan India
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- Joana M. Silva
- Life and Health Sciences Research Institute (ICVS) Medical School University of Minho Braga Portugal
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- Shripriya Singh
- CSIR‐Indian Institute of Toxicology Research Lucknow India
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- Kunjbihari Sulakhiya
- Department of Pharmacy Indira Gandhi National Tribal University Amarkantak India
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- Tesfaye Wolde Tefera
- School of Biomedical Sciences The University of Queensland Brisbane Queensland Australia
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- Behnam Vafadari
- Institute of environmental medicine UNIKA‐T Technical University of Munich Munich Germany
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- Anuradha Yadav
- CSIR‐Indian Institute of Toxicology Research Lucknow India
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- Reiji Yamazaki
- Tokyo University of Pharmacy and Life Sciences Tokyo Japan
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- Constanze I. Seidenbecher
- Department of Neurochemistry and Molecular Biology Leibniz Institute for Neurobiology Magdeburg Magdeburg Germany
抄録
<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry Advanced School, we address the basic concepts of brain energy metabolism and approach the question of why the brain has high energy expenditure. Our review illustrates that the vertebrate brain has a high need for energy because of the high number of neurons and the need to maintain a delicate interplay between energy metabolism, neurotransmission, and plasticity. Disturbances to the energetic balance, to mitochondria quality control or to glia–neuron metabolic interaction may lead to brain circuit malfunction or even severe disorders of the <jats:styled-content style="fixed-case">CNS</jats:styled-content>. We cover neuronal energy consumption in neural transmission and basic (‘housekeeping’) cellular processes. Additionally, we describe the most common (glucose) and alternative sources of energy namely glutamate, lactate, ketone bodies, and medium chain fatty acids. We discuss the multifaceted role of non‐neuronal cells in the transport of energy substrates from circulation (pericytes and astrocytes) and in the supply (astrocytes and microglia) and usage of different energy fuels. Finally, we address pathological consequences of disrupted energy homeostasis in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:label /><jats:p> <jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/png" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/jnc14829-fig-0003-m.png"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text> </jats:p></jats:sec>
収録刊行物
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- Journal of Neurochemistry
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Journal of Neurochemistry 151 (2), 139-165, 2019-09-10
Wiley