<i>β</i>-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (<i>Commiphora gileadensis</i>), Is a Selective Apoptosis Inducer for Tumor Cell Lines
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- Eitan Amiel
- French Associates Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boqer Campus, Midreshet Ben Gurion 84990, Israel
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- Rivka Ofir
- Dead Sea and Arava Science Center, the Dead Sea 86910, Israel
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- Nativ Dudai
- The Unit of Medicinal and Aromatic Plants, Newe Ya'ar Research Center, Ramat Ishai 30095, Israel
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- Elaine Soloway
- Department of Microbiology & Immunology, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
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- Tatiana Rabinsky
- Center for Sustainable Agriculture, Arava Institute for Environmental Studies, D.N. Hevel Eilot 88840, Israel
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- Shimon Rachmilevitch
- French Associates Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boqer Campus, Midreshet Ben Gurion 84990, Israel
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説明
<jats:p>The biblical balm of Gilead (<jats:italic>Commiphora gileadensis</jats:italic>) was investigated in this study for anticancerous activity against tumor cell lines. The results obtained from ethanol-based extracts and from essential oils indicated that<jats:italic>β</jats:italic>-caryophyllene (trans-(1R,9S)-8-methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene) is a key component in essential oils extracted from the balm of Gilead.<jats:italic>β</jats:italic>-Caryophyllene can be found in spice blends, citrus flavors, soaps, detergents, creams, and lotions, as well as in a variety of food and beverage products, and it is known for its anti-inflammatory, local anaesthetic, and antifungal properties. It is also a potent cytotoxic compound over a wide range of cell lines. In the current paper, we found that<jats:italic>Commiphora gileadensis</jats:italic>stem extracts and essential oil have an antiproliferative proapoptotic effect against tumor cells and not against normal cells.<jats:italic>β</jats:italic>-caryophyllene caused a potent induction of apoptosis accompanied by DNA ladder and caspase-3 catalytic activity in tumor cell lines. In summary, we showed that<jats:italic>C. gileadensis</jats:italic>stems contain an apoptosis inducer that acts, in a selective manner, against tumor cell lines and not against normal cells.</jats:p>
収録刊行物
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- Evidence-Based Complementary and Alternative Medicine
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Evidence-Based Complementary and Alternative Medicine 2012 1-8, 2012
Hindawi Limited
