High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling
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- Gloria A. Brar
- Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, and California Institute for Quantitative Biosciences, San Francisco, CA 94158, USA.
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- Moran Yassour
- Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
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- Nir Friedman
- School of Engineering and Computer Science, Hebrew University, Jerusalem 91904, Israel.
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- Aviv Regev
- Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
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- Nicholas T. Ingolia
- Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, and California Institute for Quantitative Biosciences, San Francisco, CA 94158, USA.
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- Jonathan S. Weissman
- Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, and California Institute for Quantitative Biosciences, San Francisco, CA 94158, USA.
抄録
<jats:title>Monitoring Meiosis</jats:title> <jats:p> During meiosis, or in yeast sporulation, haploid cells are generated from diploid cells. <jats:bold> Brar <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="552" related-article-type="in-this-issue" vol="335" xlink:href="10.1126/science.1215110">552</jats:related-article> , published online 22 December) performed a detailed analysis of messenger RNA (mRNA) abundance and protein synthesis over the course of sporulation. The production of most proteins was tightly regulated both at the mRNA level and by translational control. An unexpected complexity was observed as the cell passed through this key developmental transition, including increases in noncanonical translation from upstream regions of known RNA transcripts, which appear to be important in translational control. </jats:p>
収録刊行物
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- Science
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Science 335 (6068), 552-557, 2012-02-03
American Association for the Advancement of Science (AAAS)