Mathematical Modeling of Skin Bioheat Transfer

<jats:p>Advances in laser, microwave, and similar technologies have led to recent developments of thermal treatments for disease and injury involving skin tissue. In spite of the widespread use of heating therapies in dermatology, they do not draw upon the detailed understanding of the biothermomechanics of behavior, for none exists to date, even though each behavioral facet is well established and understood. It is proposed that a detailed understanding of the coupled biological-mechanical response under thermal agitation will contribute to the design, characterization, and optimization of strategies for delivering better treatment. For a comprehensive understanding on the underlying mechanisms of thermomechanical behavior of skin tissue, recent progress on bioheat transfer, thermal damage, thermomechanics, and thermal pain should be systematically reviewed. This article focuses on the transfer of heat through skin tissue. Experimental study, theoretical analysis, and numerical modeling of skin thermal behavior are reviewed, with theoretical analysis carried out and closed-form solutions obtained for simple one-layer Fourier theory based model. Non-Fourier bioheat transfer models for skin tissue are discussed, and various skin cooling technologies summarized. Finally, the predictive capacity of various heat transfer models is demonstrated with selected case studies.</jats:p>