Definition of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies
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- Mervyn D.I. Vergouwen
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Marinus Vermeulen
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Jan van Gijn
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Gabriel J.E. Rinkel
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Eelco F. Wijdicks
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- J. Paul Muizelaar
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- A. David Mendelow
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Seppo Juvela
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Howard Yonas
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Karel G. Terbrugge
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- R. Loch Macdonald
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Michael N. Diringer
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Joseph P. Broderick
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Jens P. Dreier
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
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- Yvo B.W.E.M. Roos
- From the Department of Neurology (M.D.I.V., M.V., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, the Netherlands; Division of Neurology (M.D.I.V.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Neurology (J.v.G., G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.F.W.), Mayo Clinic, Rochester, Minn, USA; Department of Neurological Surgery (J.P.M.), University of California Davis Health System,...
書誌事項
- タイトル別名
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- Proposal of a Multidisciplinary Research Group
説明
<jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this inconsistency is the combining of radiographic evidence of vasospasm with clinical features of cerebral ischemia, although multiple factors may contribute to DCI. The second issue is the variability and overlap of terms used to describe each phenomenon. This makes comparisons among studies difficult. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> An international ad hoc panel of experts involved in subarachnoid hemorrhage research developed and proposed a definition of DCI to be used as an outcome measure in clinical trials and observational studies. We used a consensus-building approach. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> It is proposed that in observational studies and clinical trials aiming to investigate strategies to prevent DCI, the 2 main outcome measures should be: (1) cerebral infarction identified on CT or MRI or proven at autopsy, after exclusion of procedure-related infarctions; and (2) functional outcome. Secondary outcome measure should be clinical deterioration caused by DCI, after exclusion of other potential causes of clinical deterioration. Vasospasm on angiography or transcranial Doppler can also be used as an outcome measure to investigate proof of concept but should be interpreted in conjunction with DCI or functional outcome. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusion—</jats:italic> </jats:bold> The proposed measures reflect the most relevant morphological and clinical features of DCI without regard to pathogenesis to be used as an outcome measure in clinical trials and observational studies. </jats:p>
収録刊行物
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- Stroke
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Stroke 41 (10), 2391-2395, 2010-10
Ovid Technologies (Wolters Kluwer Health)
