Effect of <i>Uncariae Ramulus</i> et Uncus on Endothelium in Spontaneously Hypertensive Rats
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- Hirozo Goto
- Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0154, Japan
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- Yutaka Shimada
- Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0154, Japan
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- Kiyoaki Tanigawa
- Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0154, Japan
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- Nobuyasu Sekiya
- Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0154, Japan
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- Takahiro Shintani
- Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0154, Japan
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- Katsutoshi Terasawa
- Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0154, Japan
Description
<jats:p> The protective effect of the extract of Uncariae ramulus et Uncus (URE) against endothelium disorder due to hypertension was investigated. We administered low (150 mg/kg/day) and high (450 mg/kg/day) doses of URE orally to spontaneously hypertensive rats for 8 weeks. Endothelium dependent vasodilatation by acetylcholine increased significantly in the high URE group compared with the control group. Endothelium dependent vasocontraction by xanthine oxidase decreased significantly in the high URE group compared with the control group. Serum NO<jats:sub>2</jats:sub><jats:sup>-</jats:sup>/NO<jats:sub>3</jats:sub><jats:sup>-</jats:sup> were tended to increase in the high URE group. It is suggested that URE may have a protective effect for the endothelium against the influence of hypertension. </jats:p>
Journal
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- The American Journal of Chinese Medicine
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The American Journal of Chinese Medicine 27 (03n04), 339-345, 1999-01
World Scientific Pub Co Pte Lt
