Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire
抄録
<jats:title>Abstract</jats:title><jats:p>Electrically conductive pili from <jats:italic>Geobacter</jats:italic> species, termed bacterial nanowires, are intensely studied for their biological significance and potential in the development of new materials. Using cryo-electron microscopy, we have characterized nanowires from conductive <jats:italic>G. sulfurreducens</jats:italic> pili preparations that are composed solely of head-to-tail stacked monomers of the six-heme C-type cytochrome OmcS. The unique fold of OmcS — closely wrapped around a continuous stack of hemes that can serve as an uninterrupted path for electron transport — generates a scaffold that supports the unbranched chain of hemes along the central axis of the filament. We present here, at 3.4 Å resolution, the structure of this cytochrome-based filament and discuss its possible role in long-range biological electron transport.</jats:p>
収録刊行物
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- Communications Biology
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Communications Biology 2 (1), 219-, 2019-06-19
Springer Science and Business Media LLC