Requirement for V <sub>α</sub> 14 NKT Cells in IL-12-Mediated Rejection of Tumors

DOI Web Site PubMed 被引用文献93件
  • Junqing Cui
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Tahiro Shin
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Tetsu Kawano
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Hiroshi Sato
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Eisuke Kondo
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Isao Toura
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Yoshikatsu Kaneko
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Haruhiko Koseki
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Masamoto Kanno
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
  • Masaru Taniguchi
    Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.

書誌事項

公開日
1997-11-28
DOI
  • 10.1126/science.278.5343.1623
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> A lymphocyte subpopulation, the V <jats:sub>α</jats:sub> 14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the V <jats:sub>α</jats:sub> 14 and J <jats:sub>α</jats:sub> 281 gene segments. Mice with a deletion of the J <jats:sub>α</jats:sub> 281 gene segment were found to exclusively lack this subpopulation. The V <jats:sub>α</jats:sub> 14 NKT cell–deficient mice could no longer mediate the interleukin-12 (IL-12)–induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, V <jats:sub>α</jats:sub> 14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12. </jats:p>

収録刊行物

  • Science

    Science 278 (5343), 1623-1626, 1997-11-28

    American Association for the Advancement of Science (AAAS)

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