Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite of the Human Malaria Parasite <i>Plasmodium falciparum</i>

DOI Web Site 被引用文献7件
  • John B. Dame
    Laboratory of Parasitic Diseases, at the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205.
  • Jackie L. Williams
    Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20037.
  • Thomas F. McCutchan
    Laboratory of Parasitic Diseases, at the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205.
  • James L. Weber
    Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20037.
  • Robert A. Wirtz
    Department of Entomology, Walter Reed Army Institute of Research, Washington, D.C. 20037.
  • Wayne T. Hockmeyer
    Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20037.
  • W. Lee Maloy
    Laboratory of Immunogenetics, at the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205.
  • J. David Haynes
    Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20037.
  • Imogene Schneider
    Department of Entomology, Walter Reed Army Institute of Research, Washington, D.C. 20037.
  • Donald Roberts
    Department of Entomology, Walter Reed Army Institute of Research, Washington, D.C. 20037.
  • Greg S. Sanders
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health.
  • E. Premkumar Reddy
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health.
  • Carter L. Diggs
    Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20037.
  • Louis H. Miller
    Laboratory of Parasitic Diseases, at the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205.

抄録

<jats:p> The gene for the circumsporozoite (CS) protein of <jats:italic>Plasmodium falciparum</jats:italic> has been cloned and its nucleotide sequence determined. The gene encodes a protein of 412 amino acids as deduced from the nucleotide sequence. The protein contains 41 tandem repeats of a tetrapeptide, 37 of which are Asn-Ala-Asn-Pro and four of which are Asn-Val-Asp-Pro. Monoclonal antibodies against the CS protein of <jats:italic>Plasmodium falciparum</jats:italic> were inhibited from binding to the protein by synthetic peptides of the repeat sequence. The CS protein of <jats:italic>Plasmodium falciparum</jats:italic> and the CS protein of a simian malaria parasite, <jats:italic>Plasmodium knowlesi</jats:italic> , have two regions of homology, one of which is present on either side of the repeat. One region contains 12 of 13 identical amino acids. Within the nucleotide sequence of this region, 25 of 27 nucleotides are conserved. The conservation of these regions in parasites widely separated in evolution suggests that they may have a function such as binding to liver cells and may represent an invariant target for immunity. </jats:p>

収録刊行物

  • Science

    Science 225 (4662), 593-599, 1984-08-10

    American Association for the Advancement of Science (AAAS)

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