Pacific Populations, Metabolic Disease and ‘Just‐So Stories’: A Critique of the ‘Thrifty Genotype’ Hypothesis in Oceania
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- Anna L. Gosling
- Department of Biochemistry University of Otago Dunedin New Zealand
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- Hallie R. Buckley
- Department of Anatomy University of Otago Dunedin New Zealand
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- Elizabeth Matisoo‐Smith
- Department of Anatomy University of Otago Dunedin New Zealand
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- Tony R. Merriman
- Department of Biochemistry University of Otago Dunedin New Zealand
書誌事項
- 公開日
- 2015-09-29
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/ahg.12132
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Summary</jats:title><jats:p>Pacific populations have long been observed to suffer a high burden of metabolic disease, including obesity, type 2 diabetes and gout. The ‘Thrifty Genotype’ hypothesis has frequently been used to explain this high prevalence of disease. Here, the ‘Thrifty Genotype’ hypothesis and the evolutionary background of Pacific populations are examined. We question its relevance not only in the Pacific region but more generally. Not only has the hypothesis not been explicitly tested, but most archaeological and anthropological data from the Pacific fundamentally do not support its application.</jats:p>
収録刊行物
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- Annals of Human Genetics
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Annals of Human Genetics 79 (6), 470-480, 2015-09-29
Wiley
