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- Christopher W. Wilson
- Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA.
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- Pao-Tien Chuang
- Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA.
書誌事項
- 公開日
- 2010-07-01
- DOI
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- 10.1242/dev.045021
- 公開者
- The Company of Biologists
この論文をさがす
説明
<jats:p>Hedgehog (Hh) signaling is required for embryonic patterning and postnatal physiology in invertebrates and vertebrates. With the revelation that the primary cilium is crucial for mammalian Hh signaling, the prevailing view that Hh signal transduction mechanisms are conserved across species has been challenged. However, more recent progress on elucidating the function of core Hh pathway cytosolic regulators in Drosophila, zebrafish and mice has confirmed that the essential logic of Hh transduction is similar between species. Here, we review Hh signaling events at the membrane and in the cytosol, and focus on parallel and divergent functions of cytosolic Hh regulators in Drosophila and mammals.</jats:p>
収録刊行物
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- Development
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Development 137 (13), 2079-2094, 2010-07-01
The Company of Biologists
