Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications
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- Kawssar Harb
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
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- Elia Magrinelli
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
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- Céline S Nicolas
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
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- Nikita Lukianets
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
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- Laura Frangeul
- Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland
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- Mariel Pietri
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
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- Tao Sun
- Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, United States
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- Guillaume Sandoz
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
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- Franck Grammont
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
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- Denis Jabaudon
- Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland
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- Michèle Studer
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
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- Christian Alfano
- Institut de Biologie Valrose, University of Nice Sophia Antipolis, Nice, France
Description
<jats:p>During cortical development, the identity of major classes of long-distance projection neurons is established by the expression of molecular determinants, which become gradually restricted and mutually exclusive. However, the mechanisms by which projection neurons acquire their final properties during postnatal stages are still poorly understood. In this study, we show that the number of neurons co-expressing Ctip2 and Satb2, respectively involved in the early specification of subcerebral and callosal projection neurons, progressively increases after birth in the somatosensory cortex. Ctip2/Satb2 postnatal co-localization defines two distinct neuronal subclasses projecting either to the contralateral cortex or to the brainstem suggesting that Ctip2/Satb2 co-expression may refine their properties rather than determine their identity. Gain- and loss-of-function approaches reveal that the transcriptional adaptor Lmo4 drives this maturation program through modulation of epigenetic mechanisms in a time- and area-specific manner, thereby indicating that a previously unknown genetic program postnatally promotes the acquisition of final subtype-specific features.</jats:p>
Journal
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- eLife
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eLife 5 e09531-, 2016-01-27
eLife Sciences Publications, Ltd
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Details 詳細情報について
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- CRID
- 1361418519311459456
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- ISSN
- 2050084X
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- Data Source
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- Crossref