Relation of Neutrophil to Lymphocyte Ratio With the Presence and Severity of Stable Coronary Artery Disease

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  • Ahmet Kaya
    Department of Cardiology, Ordu University Medical School, Ordu, Turkey
  • Mustafa Kurt
    Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey
  • Ibrahim Halil Tanboga
    Department of Cardiology, Ataturk University Medical School, Erzurum, Turkey
  • Turgay Işık
    Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey
  • Zeki Yüksel Günaydın
    Department of Cardiology, Ordu University Medical School, Ordu, Turkey
  • Yasemin Kaya
    Internal Medicine, Erzurum Education and Research Hospital, Erzurum, Turkey
  • Selim Topçu
    Department of Cardiology, Ataturk University Medical School, Erzurum, Turkey
  • Serdar Sevimli
    Department of Cardiology, Ataturk University Medical School, Erzurum, Turkey

抄録

<jats:sec><jats:title>Objectives:</jats:title><jats:p> We examined the association between neutrophil to lymphocyte ratio (NLR) and the complexity of coronary artery disease assessed by SYNTAX score (SS). </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> The study population included patients with chest pain who had undergone coronary angiography for stable angina pectoris. Patients were classified depending on whether the SS was 0 or SS > 0. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Left ventricular ejection fraction, estimated glomerular filtration rate, and NLR were found to be the independent predictors of high SS in multivariate analysis. The area under the receiver–operating curve of NLR was 0.72 (0.65-0.80, P < .001) for predicting high SS. The optimal cutoff value of NLR to predict high SS was 2.7 (sensitivity of 72% and a specificity of 61%). There was a significant correlation between NLR ratio and continuous SS ( r = .552, P < .001). </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> The NLR is a readily measurable systemic inflammatory marker and is associated with both the presence and the complexity of coronary artery disease. </jats:p></jats:sec>

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