GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING
-
- Tomohiro Kurosaki
- Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan;
Search this article
Description
<jats:p>▪ Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-γ2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-γ2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future.</jats:p>
Journal
-
- Annual Review of Immunology
-
Annual Review of Immunology 17 (1), 555-592, 1999-04
Annual Reviews
- Tweet
Details 詳細情報について
-
- CRID
- 1361418519373739648
-
- NII Article ID
- 30022121780
-
- NII Book ID
- AA10636710
-
- ISSN
- 15453278
- 07320582
-
- Data Source
-
- Crossref
- CiNii Articles