Identification of Virulence-Associated Properties by Comparative Genome Analysis of Streptococcus pneumoniae, S. pseudopneumoniae, S. mitis, Three S. oralis Subspecies, and <i>S. infantis</i>
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- Mogens Kilian
- Department of Biomedicine, Aarhus University, Aarhus, Denmark
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- Hervé Tettelin
- Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA
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- N. Luisa Hiller
- editor
説明
<jats:p> <jats:named-content content-type="genus-species">Streptococcus pneumoniae</jats:named-content> is one of the most important human pathogens but is closely related to <jats:named-content content-type="genus-species">Streptococcus mitis</jats:named-content> , with which humans live in harmony. The fact that the two species evolved from a common ancestor provides a unique basis for studies of both infection-associated properties and properties important for harmonious coexistence with the host. By detailed comparisons of genomes of the two species and other related streptococci, we identified 224 genes associated with virulence and 25 genes unique to the mutualistic species. The exclusive presence of the virulence factors in <jats:named-content content-type="genus-species">S. pneumoniae</jats:named-content> enhances their potential as vaccine components, as a direct impact on beneficial members of the commensal microbiota can be excluded. Successful adaptation of <jats:named-content content-type="genus-species">S. mitis</jats:named-content> and other commensal streptococci to a harmonious relationship with the host relied on genetic stability and properties facilitating life in biofilms. </jats:p>
収録刊行物
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- mBio
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mBio 10 (5), 2019-10-29
American Society for Microbiology