1′S-1′-Acetoxychavicol acetate isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 replication by blocking Rev transport
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- Ying Ye
- Department of Biomedical Sciences and the Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, People's Republic of China
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- Baoan Li
- Department of Biomedical Sciences and the Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, People's Republic of China
抄録
<jats:p>AIDS remains a major global health concern. Despite a number of therapeutic advancements, there is still an urgent need to develop a new class of therapy for human immunodeficiency virus (HIV). Here, it was shown that 1′<jats:italic>S</jats:italic>-1′-acetoxychavicol acetate (ACA), a small molecular compound isolated from the rhizomes of <jats:italic>Alpinia galanga</jats:italic>, inhibited Rev transport at a low concentration by binding to chromosomal region maintenance 1 and accumulating full-length HIV-1 RNA in the nucleus, resulting in a block in HIV-1 replication in peripheral blood mononuclear cells. Additionally, ACA and didanosine acted synergistically to inhibit HIV-1 replication. Thus, ACA may represent a novel treatment for HIV-1 infection, especially in combination with other anti-HIV drugs.</jats:p>
収録刊行物
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- Journal of General Virology
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Journal of General Virology 87 (7), 2047-2053, 2006-07-01
Microbiology Society