Acquisition of 1,000 eubacterial genes physiologically transformed a methanogen at the origin of Haloarchaea
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- Shijulal Nelson-Sathi
- Institute of Molecular Evolution,
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- Tal Dagan
- Institute of Genomic Microbiology,
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- Giddy Landan
- Institute of Molecular Evolution,
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- Arnold Janssen
- Mathematisches Institut, Heinrich Heine University, 40225 Düsseldorf, Germany;
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- Mike Steel
- Biomathematics Research Centre, University of Canterbury, Private Bag 4800, Christchurch, New Zealand;
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- James O. McInerney
- Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland; and
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- Uwe Deppenmeier
- Institute of Microbiology and Biotechnology, University of Bonn, 53115 Bonn, Germany
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- William F. Martin
- Institute of Molecular Evolution,
書誌事項
- 公開日
- 2012-11-26
- DOI
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- 10.1073/pnas.1209119109
- 公開者
- Proceedings of the National Academy of Sciences
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説明
<jats:p>Archaebacterial halophiles (Haloarchaea) are oxygen-respiring heterotrophs that derive from methanogens—strictly anaerobic, hydrogen-dependent autotrophs. Haloarchaeal genomes are known to have acquired, via lateral gene transfer (LGT), several genes from eubacteria, but it is yet unknown how many genes the Haloarchaea acquired in total and, more importantly, whether independent haloarchaeal lineages acquired their genes in parallel, or as a single acquisition at the origin of the group. Here we have studied 10 haloarchaeal and 1,143 reference genomes and have identified 1,089 haloarchaeal gene families that were acquired by a methanogenic recipient from eubacteria. The data suggest that these genes were acquired in the haloarchaeal common ancestor, not in parallel in independent haloarchaeal lineages, nor in the common ancestor of haloarchaeans and methanosarcinales. The 1,089 acquisitions include genes for catabolic carbon metabolism, membrane transporters, menaquinone biosynthesis, and complexes I–IV of the eubacterial respiratory chain that functions in the haloarchaeal membrane consisting of diphytanyl isoprene ether lipids. LGT on a massive scale transformed a strictly anaerobic, chemolithoautotrophic methanogen into the heterotrophic, oxygen-respiring, and bacteriorhodopsin-photosynthetic haloarchaeal common ancestor.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 109 (50), 20537-20542, 2012-11-26
Proceedings of the National Academy of Sciences