-
- Patrick Narbonne
- Département de Biologie Médicale, Université du Québec à Trois-Rivières, Canada
書誌事項
- 公開日
- 2018-01-01
- 権利情報
-
- https://journals.sagepub.com/page/policies/text-and-data-mining-license
- DOI
-
- 10.1177/2155179018773756
- 公開者
- SAGE Publications
この論文をさがす
説明
<jats:p> During development, stem cells generate all of the differentiated cells that populate our tissues and organs. Stem cells are also responsible for tissue turnover and repair in adults, and as such, they hold tremendous promise for regenerative therapy. Aging, however, impairs the function of stem cells and is thus a significant roadblock to using stem cells for therapy. Paradoxically, the patients who would benefit the most from regenerative therapies are usually advanced in age. The use of stem cells from young donors or the rejuvenation of aged patient-derived stem cells may represent part of a solution. Nonetheless, the transplantation success of young or rejuvenated stem cells in aged patients is still problematic, since stem cell function is greatly influenced by extrinsic factors that become unsupportive with age. This article briefly reviews how aging impairs stem cell function, and how this has an impact on the use of stem cells for therapy. </jats:p>
収録刊行物
-
- Cell Medicine
-
Cell Medicine 10 215517901877375-, 2018-01-01
SAGE Publications