-
- Wei Wei Pang
- University of Malaya Centre for Proteomics Research, University of Malaya, Kuala Lumpur - Malaysia
-
- Puteri Shafinaz Abdul-Rahman
- University of Malaya Centre for Proteomics Research, University of Malaya, Kuala Lumpur - Malaysia
-
- Wan Izlina Wan-Ibrahim
- Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur - Malaysia
-
- Onn Haji Hashim
- University of Malaya Centre for Proteomics Research, University of Malaya, Kuala Lumpur - Malaysia
書誌事項
- 公開日
- 2010-01
- 権利情報
-
- https://journals.sagepub.com/page/policies/text-and-data-mining-license
- DOI
-
- 10.1177/172460081002500101
- 公開者
- SAGE Publications
この論文をさがす
説明
<jats:p>The association between the acute-phase reactant proteins (APRPs) and cancer has long been established. There have been numerous reports correlating altered levels of various APRPs with different types of cancers. However, researchers are often quick to dismiss the use of these APRPs as potential biomarkers for the diagnosis and monitoring of cancer because alterations in APRP concentrations are observed in a wide range of diseases. Recent progress in proteomics studies which profiled the serum proteins of cancer patients and those of normal individuals indicated that the altered APRP expressions were different for distinct types, subtypes, and even stages of cancer. Interestingly, these data are in agreement with those observed earlier using immunochemical and biochemical assays. In view of this compelling association of different patterns of APRPs with various types of cancers and in an apparent shift of paradigm, we present in this review some indications that APRP fingerprinting may be used as complementary cancer biomarkers.</jats:p>
収録刊行物
-
- The International Journal of Biological Markers
-
The International Journal of Biological Markers 25 (1), 1-11, 2010-01
SAGE Publications