Strong Binding in the DNA Minor Groove by an Aromatic Diamidine with a Shape That Does Not Match the Curvature of the Groove

  • Binh Nguyen
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, INSERM U-524 IRCL, Place de Verdun, 59045 Lille, France, and Swiss Tropical Institute, CH-4002 Basel, Switzerland
  • Michael P. H. Lee
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, INSERM U-524 IRCL, Place de Verdun, 59045 Lille, France, and Swiss Tropical Institute, CH-4002 Basel, Switzerland
  • Donald Hamelberg
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, INSERM U-524 IRCL, Place de Verdun, 59045 Lille, France, and Swiss Tropical Institute, CH-4002 Basel, Switzerland
  • Alexandra Joubert
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, INSERM U-524 IRCL, Place de Verdun, 59045 Lille, France, and Swiss Tropical Institute, CH-4002 Basel, Switzerland
  • Christian Bailly
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, INSERM U-524 IRCL, Place de Verdun, 59045 Lille, France, and Swiss Tropical Institute, CH-4002 Basel, Switzerland
  • Reto Brun
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, INSERM U-524 IRCL, Place de Verdun, 59045 Lille, France, and Swiss Tropical Institute, CH-4002 Basel, Switzerland
  • Stephen Neidle
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, INSERM U-524 IRCL, Place de Verdun, 59045 Lille, France, and Swiss Tropical Institute, CH-4002 Basel, Switzerland
  • W. David Wilson
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, INSERM U-524 IRCL, Place de Verdun, 59045 Lille, France, and Swiss Tropical Institute, CH-4002 Basel, Switzerland

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