書誌事項
- 公開日
- 2011-02-23
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1600-065x.2010.00999.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:p><jats:bold>Summary: </jats:bold> <jats:italic>Salmonella enterica</jats:italic> is a genetically broad species harboring isolates that display considerable antigenic heterogeneity and significant differences in virulence potential. <jats:italic>Salmonella</jats:italic> generally exhibit an invasive potential and they can survive for extended periods within cells of the immune system. They cause acute or chronic infections that can be local (e.g. gastroenteritis) or systemic (e.g. typhoid). <jats:italic>In vivo Salmonella</jats:italic> infections are complex with multiple arms of the immune system being engaged. Both humoral and cellular responses can be detected and characterized, but full protective immunity is not always induced, even following natural infection. The murine model has proven to be a fertile ground for exploring immune mechanisms and observations in the mouse have often, although not always, correlated with those in other infectable species, including humans. Host genetic studies have identified a number of mammalian genes that are central to controlling infection, operating both in innate and acquired immune pathways. Vaccines, both oral and parenteral, are available or under development, and these have been used with some success to explore immunity in both model systems and clinically in humans.</jats:p>
収録刊行物
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- Immunological Reviews
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Immunological Reviews 240 (1), 196-210, 2011-02-23
Wiley