Diastereoselective reduction of α-aminoketones: Synthesis of <i>anti</i>- and <i>syn</i>-β-aminoalcohols
書誌事項
- 公開日
- 2004-02-01
- 権利情報
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- http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining
- DOI
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- 10.1139/v03-165
- 公開者
- Canadian Science Publishing
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説明
<jats:p> Reduction of N-t-BOC-protected-N-alkyl α-aminoketones with LiEt<jats:sub>3</jats:sub>BH or Li(s-Bu)<jats:sub>3</jats:sub>BH furnishes protected syn-β-aminoalcohols with high selectivities. In contrast, removal of the BOC group followed by reduction of the aminoketone gives anti-β-aminoalcohols with variable selectivities. With aromatic ketones, selectivities are typically high while aliphatic ketones show mediocre to high selectivities depending on steric considerations.Key words: β-aminoalcohol, diastereoselective reduction. </jats:p>
収録刊行物
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- Canadian Journal of Chemistry
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Canadian Journal of Chemistry 82 (2), 87-101, 2004-02-01
Canadian Science Publishing
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詳細情報 詳細情報について
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- CRID
- 1361418519982736128
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- DOI
- 10.1139/v03-165
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- ISSN
- 14803291
- 00084042
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- データソース種別
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- Crossref
