Sensing of DNA damage by XPC/Rad4: one protein for many lesions

書誌事項

公開日
2007-10
権利情報
  • http://www.springer.com/tdm
DOI
  • 10.1038/nsmb1007-887
公開者
Springer Science and Business Media LLC

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説明

Through its crucial role in DNA damage recognition and initiation of nucleotide excision repair in mammals, XPC protein represents a first line of defense against carcinogenesis. The recent elucidation of the molecular structure of the yeast XPC homolog Rad4 provides new insights into how eukaryotic cells recognize structurally diverse DNA lesions.

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