Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery
書誌事項
- 公開日
- 2007-02-01
- 権利情報
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- https://www.springer.com/tdm
- https://www.springer.com/tdm
- DOI
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- 10.1038/sj.gt.3302910
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
This study describes a multifunctional envelope-type nano device (MEND) that mimics an envelope-type virus based on a novel packaging strategy. MEND particles contain a DNA core packaged into a lipid envelope modified with an octaarginine peptide. The peptide mediates internalization via macropinocytosis, which avoids lysosomal degradation. MEND-mediated transfection of a luciferase expression plasmid achieved comparable efficiency to adenovirus-mediated transfection, with lower associated cytotoxicity. Furthermore, topical application of MEND particles containing constitutively active bone morphogenetic protein (BMP) type IA receptor (caBmpr1a) gene had a significant impact on hair growth in vivo. These data demonstrate that MEND is a promising non-viral gene delivery system that may provide superior results to existing non-viral gene delivery technologies.
収録刊行物
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- Gene Therapy
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Gene Therapy 14 (8), 682-689, 2007-02-01
Springer Science and Business Media LLC