ATTENUATION OF PRESSOR RESPONSES TO SYMPATHETIC STIMULI IN THE RAT BY ENALAPRIL
説明
<jats:title>SUMMARY</jats:title><jats:p>1. Intravenous administration to pithed Wistar rats of the angiotensin converting enzyme inhibitor enalapril (0.1–1.0 mg/kg) lowered the diastolic blood pressure and reduced pressor responses occurring during electrical stimulation (1–30 Hz) of the spinal sympathetic outflow.</jats:p><jats:p>2. These doses of enalapril given intravenously also attenuated pressor responses to intravenous injection of the muscarinic ganglion stimulant McNeil‐A‐343 (50, 100, 150 μg/kg) and noradrenaline (0.1–5.0 μg/kg). Enalapril (1.0 mg/kg, i. v.) reduced pressor responses to the nicotinic ganglion stimulant 1,1‐dimethyl‐4‐phenylpiperazinium (300 μg/kg, i.v.).</jats:p><jats:p>3. These results confirmed that the actions of enalapril resemble those of captopril in the pithed rat, by causing reductions in both blood pressure and pressor responses to sympathetic stimuli.</jats:p>
収録刊行物
-
- Clinical and Experimental Pharmacology and Physiology
-
Clinical and Experimental Pharmacology and Physiology 13 (9), 691-697, 1986-09
Wiley