Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory
書誌事項
- 公開日
- 2004-09-15
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1460-9568.2004.03688.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Benzodiazepines, including lorazepam, are widely used in human medicine as anxiolytics or sedatives, and at higher doses can produce amnesia. Here we demonstrate that in rats lorazepam impairs both recognition memory and synaptic plastic processes (long‐term depression and long‐term potentiation). Both impairments are produced by actions in perirhinal cortex. The findings thus establish a mechanism by means of which benzodiazepines impair recognition memory. The findings also strengthen the hypotheses that the familiarity discrimination component of recognition memory is dependent on reductions in perirhinal neuronal responses when stimuli are repeated and that these response reductions are due to a plastic mechanism also used in long‐term depression.</jats:p>
収録刊行物
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- European Journal of Neuroscience
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European Journal of Neuroscience 20 (8), 2214-2224, 2004-09-15
Wiley