HPV 16/18-associated condyloma acuminatum of the urinary bladder: first international report and review of literature

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  • M Chrisofos
    2nd Department of Urology, University of Athens, 1 Sismanogleiou Str, 151 26 Marousi, Greece
  • A Skolarikos
    2nd Department of Urology, University of Athens, 1 Sismanogleiou Str, 151 26 Marousi, Greece
  • A Lazaris
    Department of Pathology, University of Athens, 1 Sismanogleiou Str, 151 26 Marousi, Greece
  • S Bogris
    2nd Department of Urology, University of Athens, 1 Sismanogleiou Str, 151 26 Marousi, Greece
  • Ch Deliveliotis
    2nd Department of Urology, University of Athens, 1 Sismanogleiou Str, 151 26 Marousi, Greece

Description

<jats:p> Condyloma acuminatum is an anogenital lesion caused by human papillomavirus (HPV) infection, a common sexually transmitted disease. It usually affects the external genitalia while urethral and/or bladder involvement is rare. HPV types are classified into three categories depending on their oncogenic potential: low risk (type 6, 11, 42, 43, 44, 59, 66, 68, 70), intermediate risk (type 30, 31, 33, 34, 35, 39, 40, 49, 51, 52, 53, 57, 58, 63, 64) and high risk (type 16, 18, 45, 56). High-risk and intermediate-risk HPV-DNA types, together with other co-factors still to be defined, are responsible for over 90% of the cases of anogenital pre-malignant and malignant tumours. We report a unique case of a urinary bladder condyloma acuminatum positive for HPV 16/18 DNA, presented as the primary and only site of the disease in an immunocompetent patient. We review the treatment and follow-up strategies of this rare lesion. </jats:p>

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