Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior
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- Larry S. Zweifel
- Biochemistry and
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- Jones G. Parker
- Biochemistry and
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- Collin J. Lobb
- Department of Biology, University of Texas, San Antonio, TX 78249
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- Aundrea Rainwater
- Biochemistry and
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- Valerie Z. Wall
- Biochemistry and
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- Jonathan P. Fadok
- Biochemistry and
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- Martin Darvas
- Biochemistry and
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- Min J. Kim
- Departments of dPsychology,
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- Sheri J. Y. Mizumori
- Departments of dPsychology,
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- Carlos A. Paladini
- Department of Biology, University of Texas, San Antonio, TX 78249
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- Paul E. M. Phillips
- Psychiatry and Behavioral Sciences,
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- Richard D. Palmiter
- Biochemistry and
Abstract
<jats:p>Midbrain dopamine (DA) neurons fire in 2 characteristic modes, tonic and phasic, which are thought to modulate distinct aspects of behavior. However, the inability to selectively disrupt these patterns of activity has hampered the precise definition of the function of these modes of signaling. Here, we addressed the role of phasic DA in learning and other DA-dependent behaviors by attenuating DA neuron burst firing and subsequent DA release, without altering tonic neural activity. Disruption of phasic DA was achieved by selective genetic inactivation of NMDA-type, ionotropic glutamate receptors in DA neurons. Disruption of phasic DA neuron activity impaired the acquisition of numerous conditioned behavioral responses, and dramatically attenuated learning about cues that predicted rewarding and aversive events while leaving many other DA-dependent behaviors unaffected.</jats:p>
Journal
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 106 (18), 7281-7288, 2009-05-05
Proceedings of the National Academy of Sciences
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Details 詳細情報について
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- CRID
- 1361418520412759040
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- ISSN
- 10916490
- 00278424
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- Data Source
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- Crossref