Human Hepatocyte Growth Factor in Alcoholic Liver Disease: A Comparison with Change in α‐Fetoprotein
説明
<jats:p>To evaluate the hepatic regenerative response in patients with alcoholic liver disease, sera from 263 patients with severe alcoholic hepatitis and/or cirrhosis were analyzed for hepatocyte growth factor (HGF) and α‐fetoprotein (AFP). HGF concentration was elevated above healthy controls in 95% of the patients (median level = 2.4 ng/ml), whereas AFP tended to be depressed below controls (median level = 4.1 ng/ml). Correlations with parameters of liver injury (i.e., ascites, encephalopathy, AST bilirubin, and protime) all showed a more significant correlation with HGF concentrations than those of AFP. Patients with HGF levels below the mean (4 ng/ml) exhibited significantly better survival (median survival = 35 months vs. 8.5 months for those with HGF ≥4 ng/ml; <jats:italic>p</jats:italic>= 0.007). Serum HGF levels were associated with various specific histologic features of alcoholic hepatitis that included, but were not exclusively related to, necrosis.</jats:p>
収録刊行物
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- Alcoholism: Clinical and Experimental Research
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Alcoholism: Clinical and Experimental Research 20 (9), 1625-1630, 1996-12
Wiley
