Development of the polymer micelle carrier system for doxorubicin

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Published
2001-07
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  • https://www.elsevier.com/tdm/userlicense/1.0/
DOI
  • 10.1016/s0168-3659(01)00341-8
Publisher
Elsevier BV

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We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugated doxorubicin-polyaspartic acid. It has high hydrophobic inner core, and therefore can entrap the sufficient amount of DOX. NK911 has a small particle size of about 40 nm in diameter that accumulates in tumor tissue by EPR effect showing much stronger activity than the free DOX. We plan to perform a clinical trial at National Cancer Center Hospital, Japan from 2001.

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