A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
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- Elizabeth Clayton
- 1Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
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- Giuseppe Bardi
- 1Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
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- Sarah E. Bell
- 1Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
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- David Chantry
- 2COS Corporation, Bothell, WA 98021
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- C. Peter Downes
- 3Department of Biochemistry, University of Dundee, Dundee, DD1 5EH, United Kingdom
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- Alexander Gray
- 3Department of Biochemistry, University of Dundee, Dundee, DD1 5EH, United Kingdom
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- Lisa A. Humphries
- 4The Molecular Biology Institute, University of California, Los Angeles, CA 90095
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- David Rawlings
- 5Department of Immunology, University of Washington, School of Medicine, Seattle, WA 98195
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- Helen Reynolds
- 1Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
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- Elena Vigorito
- 1Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
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- Martin Turner
- 5Department of Immunology, University of Washington, School of Medicine, Seattle, WA 98195
説明
<jats:p>Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins, respond poorly to immunization with type II thymus-independent antigen, and are defective in their primary and secondary responses to thymus-dependent antigen. p110δ−/− B cells proliferate poorly in response to B cell receptor (BCR) or CD40 signals in vitro, fail to activate protein kinase B, and are prone to apoptosis. p110δ function is required for BCR-mediated calcium flux, activation of phosphlipaseCγ2, and Bruton's tyrosine kinase. Thus, p110δ plays a critical role in B cell homeostasis and function.</jats:p>
収録刊行物
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- The Journal of Experimental Medicine
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The Journal of Experimental Medicine 196 (6), 753-763, 2002-09-09
Rockefeller University Press
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詳細情報 詳細情報について
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- CRID
- 1361418520492078208
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- NII論文ID
- 30017416848
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- ISSN
- 15409538
- 00221007
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- データソース種別
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