One-pot synthesis of monodisperse iron oxide nanoparticles for potential biomedical applications
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- Jin Xie
- Department of Chemistry, Brown University, Providence, RI 02912, USA
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- Sheng Peng
- Department of Chemistry, Brown University, Providence, RI 02912, USA
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- Nathan Brower
- Department of Chemistry, Brown University, Providence, RI 02912, USA
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- Nader Pourmand
- Stanford Genome Technology Center, 855 California Ave., Palo Alto, CA 94304, USA
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- Shan X. Wang
- Department of Materials Science and Engineering and Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
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- Shouheng Sun
- Department of Chemistry, Brown University, Providence, RI 02912, USA
説明
<jats:title>Abstract</jats:title> <jats:p>One-pot reaction of iron(III) acetylacetonate, Fe(acac)<jats:sub>3</jats:sub>, [or Fe(acac)<jats:sub>3</jats:sub> and M(acac)<jats:sub>2</jats:sub> where M = Mn and Co], with 1,2-alkanediol, oleic acid, and oleylamine in high boiling organic solvent leads to monodisperse ferrite MFe<jats:sub>2</jats:sub>O<jats:sub>4</jats:sub> nanoparticles. Depending on the concentration of the metal precursors, surfactant-to-metal precursor ratio and the solvent used in the reaction, the particle size from this one-pot reaction can be tuned from 4 to 15 nm. The as-synthesized iron oxide nanoparticles have an inverse spinel structure, and their magnetic properties are controlled by particle size and M in the MFe<jats:sub>2</jats:sub>O<jats:sub>4</jats:sub> structure. The hydrophobic iron oxide nanoparticles are readily transformed into hydrophilic ones by functional phospholipid addition to the as-synthesized particles and as a result, the monodisperse nanoparticles are readily functionalized with biotin, -COOH, -SH, and -NH<jats:sub>2</jats:sub>, facilitating their link to biomolecules for biomedical applications.</jats:p>
収録刊行物
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- Pure and Applied Chemistry
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Pure and Applied Chemistry 78 (5), 1003-1014, 2006-01-01
Walter de Gruyter GmbH
