Gut barrier function and the surgeon

DOI PDF Web Site 被引用文献5件
  • R Saadia
    Trauma Unit, Johannesburg Hospital and The University of the Witwatersrand , Johannesburg,
  • M Schein
    Trauma Unit, Johannesburg Hospital and The University of the Witwatersrand , Johannesburg,
  • C MacFarlane
    Trauma Unit, Johannesburg Hospital and The University of the Witwatersrand , Johannesburg,
  • K D Boffard
    Trauma Unit, Johannesburg Hospital and The University of the Witwatersrand , Johannesburg,

書誌事項

公開日
1990-05-01
権利情報
  • https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
DOI
  • 10.1002/bjs.1800770505
公開者
Oxford University Press (OUP)

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説明

<jats:title>Abstract</jats:title> <jats:p>There is accumulating evidence that multiple organ failure is not always the result of an established septic focus. Increasing attention has centred on the gut as a reservoir of bacteria (and bacterial endotoxins) that can traverse the intestinal mucosal barrier (a process called ‘bacterial translocation’) and initiate the septic state. Although the link between haemorrhagic shock and sepsis was recognized decades ago, the full experimental demonstration of this phenomenon is more recent. It was shown to occur in three main settings: physical disruption of the gut mucosa, impaired defence mechanisms and altered gut microbial ecology. Conditions such as haemorrhagic shock, burns, protein malnutrition and sepsis are seen in the severely ill surgical patient or the multiply injured, and are known to cause various combinations of circumstances favourable to bacterial translocation and endotoxin absorption. These may play an important role in the mortality of the critically ill.</jats:p>

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