Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity
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- Smita Yadav
- Department of Physiology, University of California, San Francisco, CA 94158;
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- Susan H. Younger
- Department of Physiology, University of California, San Francisco, CA 94158;
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- Linghua Zhang
- The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
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- Katherine L. Thompson-Peer
- Department of Physiology, University of California, San Francisco, CA 94158;
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- Tun Li
- Department of Physiology, University of California, San Francisco, CA 94158;
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- Lily Y. Jan
- Department of Physiology, University of California, San Francisco, CA 94158;
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- Yuh Nung Jan
- Department of Physiology, University of California, San Francisco, CA 94158;
説明
<jats:title>Significance</jats:title> <jats:p> Glia and neurons, the two principal cell types of the nervous system, interact intimately and are critical for normal development and function of the nervous system. While much is known about glia interaction with axons, the architecture and importance of glia interaction with the somatodendritic neuronal compartment is practically unknown. Using <jats:italic>Drosophila</jats:italic> as a model system, we have identified important and previously unknown roles for glia interaction with the somatodendritic compartment in dendrite structure, activity, and regeneration. Furthermore, recent clinical studies have shown patients with ATRX mutations exhibit white matter and glial abnormalities in their central nervous system, underscoring the significance of our study that uncovers an essential role for glial-expressed ATRX in mediating proper glial development and function. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 116 (11), 5126-5134, 2019-02-25
Proceedings of the National Academy of Sciences
