Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis
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- Xiaocui Xu
- CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Guoqiang Li
- CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Congru Li
- CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Jing Zhang
- CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Qiang Wang
- Institute of Apiculture Research, Chinese Academy of Agriculture Sciences, Beijing 100093, China
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- David K Simmons
- Whitney Laboratory for Marine Bioscience, University of Florida, FL 32080, USA
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- Xuepeng Chen
- CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Naveen Wijesena
- Whitney Laboratory for Marine Bioscience, University of Florida, FL 32080, USA
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- Wei Zhu
- CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Zhanyang Wang
- College of Life Sciences, Yantai University, Yantai 265600, China
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- Zhenhua Wang
- College of Life Sciences, Yantai University, Yantai 265600, China
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- Bao Ju
- College of Life Sciences, Yantai University, Yantai 265600, China
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- Weimin Ci
- CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Xuemei Lu
- CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Daqi Yu
- Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
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- Qian-fei Wang
- CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
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- Neelakanteswar Aluru
- Biology Department, Woods Hole Oceanographic Institution, MA 02543, USA
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- Paola Oliveri
- Departments of Genetics, Evolution and Environment, and Cell and Developmental Biology, University College London, London WC1E 6BT, UK
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- Yong E Zhang
- Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
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- Mark Q Martindale
- Whitney Laboratory for Marine Bioscience, University of Florida, FL 32080, USA
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- Jiang Liu
- CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates and vertebrates, with numerous spectacular innovations. To search for the molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans. We focused on gametes and early embryos, where the methylomes are known to evolve divergently between fish and mammals. Here, we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects, but clearly presents in deuterostomes such as echinoderms and invertebrate chordates, and then becomes more evident in vertebrates. Functional association analysis suggests that DNA methylation reprogramming is associated with development, reproduction and adaptive immunity for vertebrates, but not for invertebrates. Interestingly, the single HOX cluster of invertebrates maintains unmethylated status in all stages examined. In contrast, the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis. Notably, the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals. Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution, especially after the evolutionary transitions from invertebrates to vertebrates, and then to mammals.</jats:p>
Journal
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- National Science Review
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National Science Review 6 (5), 993-1003, 2019-05-24
Oxford University Press (OUP)
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Details 詳細情報について
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- CRID
- 1361418520629326848
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- ISSN
- 2053714X
- 20955138
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- Data Source
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- Crossref