The enzymic conversion of <i>all</i>‐<i>cis</i> 8,11,14‐eicosatrienoic acid into prostaglandin E<sub>1</sub>
書誌事項
- 公開日
- 1966-01
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/recl.19660850412
- 公開者
- Wiley
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説明
<jats:title>Abstract</jats:title><jats:p>In the biosynthesis of prostaglandin E<jats:sub>1</jats:sub> (PGE<jats:sub>1</jats:sub>) with an enzyme fraction of sheep vesicular glands glutathione and a moderate amount of antioxidant are required to obtain maximum yield; two oxygen molecules are consumed per mole PGE<jats:sub>1</jats:sub> formed. By altering the incubation conditions, besides PGE<jats:sub>1</jats:sub> various other products can be obtained.</jats:p><jats:p>A scheme for the mechanism of the conversion is proposed in which the formation of PGE<jats:sub>1</jats:sub> as well as that of the byproducts is assumed to occur on the enzyme in concerted reactions via peroxy‐radicals and a cyclic peroxide.</jats:p>
収録刊行物
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- Recueil des Travaux Chimiques des Pays-Bas
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Recueil des Travaux Chimiques des Pays-Bas 85 (4), 405-419, 1966-01
Wiley
