Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia
書誌事項
- 公開日
- 1997-07
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- DOI
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- 10.1016/s0006-8993(97)00490-3
- 公開者
- Elsevier BV
この論文をさがす
説明
The salicylate-trapping method was used to detect hydroxyl radicals by measurement of stable adduct dihydroxybenzoic acid (DHBA). Ten minutes of forebrain ischemia followed by reperfusion induced the increase in DHBA in rat hippocampal perfusates. Postischemic treatment with a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), significantly reduced the increase in DHBA and suppressed delayed neuronal death in the hippocampal CA1 region.
収録刊行物
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- Brain Research
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Brain Research 762 (1-2), 240-242, 1997-07
Elsevier BV